MR-785B Micro Raman Spectrometer

Product Introduction

The MR-785B is HM Instruments' flagship micro Raman spectrometer, representing the convergence of near-infrared fluorescence suppression and fully automated spatial mapping. Designed for the most demanding pharmaceutical, biomedical, and advanced materials laboratories, this system combines 785 nm excitation — which virtually eliminates autofluorescence from organic and biological samples — with a precision motorized stage capable of unattended large-area chemical imaging.

The motorized X-Y platform achieves 5 μm positioning accuracy with 2 μm minimum step size across a 110 mm × 75 mm travel range, while integrated autofocus tracking compensates for surface irregularities during extended mapping sequences. The 1200 gl/mm volume phase holographic grating blazed at 800 nm, coupled with the Hamamatsu 11639 CMOS detector (2048 pixels, >99.8% linearity), delivers a wavenumber range of 200–3200 cm⁻¹ with 7 cm⁻¹ resolution — ideal for distinguishing pharmaceutical polymorphs, mapping tissue biochemistry, and characterizing complex organic mixtures.

Whether analyzing drug tablet homogeneity, mapping microplastic contamination on filter membranes, or conducting high-throughput screening of fluorescence-prone geological samples, the MR-785B provides the automation, sensitivity, and spectral quality required by leading-edge research and quality control facilities. See our Raman industry applications whitepaper for detailed use cases across sectors.

Applications

• Automated polymorph distribution mapping across pharmaceutical tablet surfaces and cross-sections
• High-throughput tissue section imaging for cancer margin assessment and pathological research
• Large-area microplastic particle scanning on environmental filter membranes with automated classification
• Drug coating uniformity and layer thickness mapping for quality control in pharmaceutical manufacturing
• Forensic trace evidence mapping with automated particle detection and spectral library matching
• Geological fluid inclusion and mineral phase mapping in fluorescence-prone host minerals
• Polymer blend morphology and additive distribution analysis across industrial sample areas
• Cultural heritage artifact analysis — pigment and binder mapping on fluorescence-rich historical surfaces

Functional Performance and Features

1. 785 nm near-infrared excitation virtually eliminates autofluorescence from organic, biological, and colored samples — the optimal wavelength for pharmaceutical and biomedical Raman analysis
2. Motorized X-Y mapping stage with 5 μm positioning accuracy and 2 μm minimum step enables automated high-resolution chemical imaging without operator intervention
3. 110 mm × 75 mm travel range supports large-area mapping of pharmaceutical tablets, tissue sections, and industrial samples in a single unattended acquisition
4. 1200 gl/mm grating blazed at 800 nm maximizes throughput at 785 nm excitation, delivering superior signal-to-noise performance for weak organic Raman scatterers
5. Hamamatsu 11639 CMOS detector with 2048 pixels and >99.8% linearity ensures quantitative accuracy for pharmaceutical polymorph quantification and tissue biochemistry mapping
6. 7 cm⁻¹ spectral resolution resolves closely related drug polymorphs (Forms I–IV), crystalline phases, and biological molecular conformations
7. Integrated autofocus tracking maintains consistent focal position across uneven tablet surfaces, tissue sections, and rough industrial samples during extended mapping runs
8. 8-hour system stability exceeding 99% enables overnight unattended mapping acquisitions of large sample grids with reliable data reproducibility
9. SpectrumFactory mapping workflow — ROI selection, automated grid acquisition, spectral preprocessing (airPLS baseline, normalization), PCA clustering, and false-color chemical image export
10. Rack-mounted microscope with 5x through 100x objectives and 25 μm spot size provides flexibility from survey-scale to single-cell-level analysis
11. SMA905 fiber optic interface, 4 GPIO outputs, and external trigger with 5 ns latency support integration with laboratory automation and LIMS systems

Main Parameters

Parameter	Value
Product Model	MR-785B
Excitation Wavelength	785 nm
Wavenumber Range	200–3200 cm⁻¹
Spectral Resolution	7 cm⁻¹
Grating	1200 gl/mm, 12.5 mm × 12.5 mm effective size, blazed at 800 nm
Detector	Hamamatsu CMOS linear array, 2048 pixels, linearity > 99.8%
Sample Stage	Motorized mapping platform, 110 mm × 75 mm travel
Positioning Accuracy	5 μm (minimum step 2 μm)
Microscope	Rack-mounted, 5x / 20x / 50x / 100x objectives
Spot Size	25 μm
Reference Price	$37,000

Technical Parameters

Parameter	Specification
Wavelength Resolution	2048 channels, 0.1 nm interval (minimum)
Signal-to-Noise Ratio	Normal mode 500:1
Acquisition Mode	Single / Continuous / External trigger / Mapping grid
Dynamic Range	3000:1
Dark Noise	20 counts
A/D Converter	16-bit, 2 MHz (maximum)
Exposure Time	0.06 ms – 65 s
Integration Time	1 ms – 65 s
Optical Slit	25 μm (default)
Fiber Optic Interface	SMA905
Data Transfer Rate	100 fps (maximum)
Digital I/O	4 programmable digital GPIO; 1 analog output (integrated laser power controller)
External Trigger	5 ns low-latency, 5 ns–65 s programmable delay, retriggerable
Connectors	30-pin connector, including USB (480 Mbps) / TTL (3.3 V) / RS232 / RS485
Stage Travel Range	X: 110 mm, Y: 75 mm
Stage Positioning Accuracy	5 μm
Stage Minimum Step	2 μm
Autofocus	Integrated focus tracking for mapping
System Stability	Laser >99.9%, Spectrometer >99.99%, Overall >99% (8-hour test after 15-min warm-up)

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